内部输入/输出错误
I'm using AF3 at the end of the pipeline after proteinMPNN design to predict the structure of the generated sequences. I have a Python script to convert the .fasta output from MPNN to an accepted .json input for AF3. This typically runs well for a while but sometimes at certain files, AF3 gets an error pasted below. I believe it's an internal error because the file at which it crashes does get loaded and goes through some iterations of MSA. The "LDKNRI…" is the sequence of the file at which it crashes. The previous file 'binder4_partdif_240_sample2' worked well and the files are generated from the same script. In the input, sequence A is the variable sequence while sequence B is the same for all the input files. Whenever I try to restart a run of AF3 with this as input file, it always fails at this file. Is there something wrong with the sequence or with how AF is run?
内容来源: google-deepmind/alphafold3