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SSL4MIS

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Semi Supervised Learning for Medical Image Segmentation, a collection of literature reviews and code implementations.

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Semi Supervised Learning for Medical Image Segmentation, a collection of literature reviews and code implementations.

Semi-supervised-learning-for-medical-image-segmentation.

  • [New] We have transferred to a new topic about active learning and source-free domain adaptation for medical image analysis, which may be closer to the real clinical requirement. The new benchmark is here.

  • We are reformatting the codebase to support the 5-fold cross-validation and randomly select labeled cases, the reformatted methods in this Branch.

  • Recently, semi-supervised image segmentation has become a hot topic in medical image computing, unfortunately, there are only a few open-source codes and datasets, since the privacy policy and others. For easy evaluation and fair comparison, we are trying to build a semi-supervised medical image segmentation benchmark to boost the semi-supervised learning research in the medical image computing community. If you are interested, you can push your implementations or ideas to this repo or contact me at any time.

  • This repo has re-implemented these semi-supervised methods (with some modifications for semi-supervised medical image segmentation, more details please refer to these original works): (1) Mean Teacher; (2) Entropy Minimization; (3) Deep Adversarial Networks; (4) Uncertainty Aware Mean Teacher; (5) Interpolation Consistency Training; (6) Uncertainty Rectified Pyramid Consistency; (7) Cross Pseudo Supervision; (8) Cross Consistency Training; (9) Deep Co-Training; (10) Cross Teaching between CNN and Transformer; (11) FixMatch; (12) Regularized Dropout. In addition, several backbones networks (both 2D and 3D) are also supported in this repo, such as UNet, nnUNet, VNet, AttentionUNet, ENet, Swin-UNet, etc.

  • This project was originally developed for our previous works. Now and future, we are still working on extending it to be more user-friendly and support more approaches to further boost and ease this topic research. If you use this codebase in your research, please cite the following works:

      @article{media2022urpc,
      title={Semi-Supervised Medical Image Segmentation via Uncertainty Rectified Pyramid Consistency},
      author={Luo, Xiangde and Wang, Guotai and Liao, Wenjun and Chen, Jieneng and Song, Tao and Chen, Yinan and Zhang, Shichuan, Dimitris N. Metaxas, and Zhang, Shaoting},
      journal={Medical Image Analysis},
      volume={80},
      pages={102517},
      year={2022},
      publisher={Elsevier}}
      
      @inproceedings{luo2021ctbct,
      title={Semi-supervised medical image segmentation via cross teaching between cnn and transformer},
      author={Luo, Xiangde and Hu, Minhao and Song, Tao and Wang, Guotai and Zhang, Shaoting},
      booktitle={International Conference on Medical Imaging with Deep Learning},
      pages={820--833},
      year={2022},
      organization={PMLR}}
    
      @InProceedings{luo2021urpc,
      author={Luo, Xiangde and Liao, Wenjun and Chen, Jieneng and Song, Tao and Chen, Yinan and Zhang, Shichuan and Chen, Nianyong and Wang, Guotai and Zhang, Shaoting},
      title={Efficient Semi-supervised Gross Target Volume of Nasopharyngeal Carcinoma Segmentation via Uncertainty Rectified Pyramid Consistency},
      booktitle={Medical Image Computing and Computer Assisted Intervention -- MICCAI 2021},
      year={2021},
      pages={318--329}}
       
      @InProceedings{luo2021dtc,
      title={Semi-supervised Medical Image Segmentation through Dual-task Consistency},
      author={Luo, Xiangde and Chen, Jieneng and Song, Tao and  Wang, Guotai},
      journal={AAAI Conference on Artificial Intelligence},
      year={2021},
      pages={8801-8809}}
      
      @misc{ssl4mis2020,
      title={{SSL4MIS}},
      author={Luo, Xiangde},
      howpublished={\\url{https://github.com/HiLab-git/SSL4MIS}},
      year={2020}}

Literature reviews of semi-supervised learning approach for medical image segmentation (SSL4MIS).

Date The First and Last Authors Title Code Reference
2025-08 J. Zhu and H. Cui CCA: Contrastive cluster assignment for supervised and semi-supervised medical image segmentation Code NN2025
2025-04 Q. Zhou and Z. Wang Single-slice Semi-supervised 3D Medical Image Segmentation via Correlation Information Enhancement and Hybrid Pseudo Mask Generation None JBHI2025
2025-04 K. Yan and Z. Liu SGTC: Semantic-Guided Triplet Co-training for Sparsely Annotated Semi-Supervised Medical Image Segmentation None AAAI2025
2025-04 H. Zhang and Y. Ma Prototype-Augmented Mean Teacher for Robust Semi-Supervised Medical Image Segmentation None PR2025
2025-04 W. Huang and L. Zhang GapMatch: Bridging Instance and Model Perturbations for Enhanced Semi-Supervised Medical Image Segmentation None AAAI2025
2025-04 Y. Wang and Y. Shi Balancing Multi-Target Semi-Supervised Medical Image Segmentation with Collaborative Generalist and Specialists Code TMI2025
2024-10 D, Abhijit and S. Roy Confidence-Guided Semi-supervised Learning for Generalized Lesion Localization in X-Ray Images Code MICCAI2024
2024-10 K. Eunjin and H. Park Semi-supervised Segmentation through Rival Networks Collaboration with Saliency Map in Diabetic Retinopathy Code MICCAI2024
2024-10 X. Liu and Y. Yuan DiffRect: Latent Diffusion Label Rectification for Semi-supervised Medical Image Segmentation Code MICCAI2024
2024-10 Z. Zhao and L. Wang Alternate Diverse Teaching for Semi-supervised Medical Image Segmentation None ECCV2024
2024-09 B. Zhao and S. Ding CrossMatch: Enhance Semi-Supervised Medical Image Segmentation with Perturbation Strategies and Knowledge Distillation Code JBHI2024
2024-06 Z, Quan and X. Zhang Robust Semi-Supervised 3D Medical Image Segmentation With Diverse Joint-Task Learning and Decoupled Inter-Student Learning Code TMI2024
2024-06 Q. Ma and Y. Shi Constructing and Exploring Intermediate Domains in Mixed Domain Semi-supervised Medical Image Segmentation Code CVPR2024
2024-06 H. Chi and B. Zhang Adaptive Bidirectional Displacement for Semi-Supervised Medical Image Segmentation Code CVPR2024
2024-05 J. Su and Z. Luo Mutual learning with reliable pseudo label for semi-supervised medical image segmentation Code MedIA2024
2024-01 Y. Ma and L. Wang Model-Heterogeneous Semi-Supervised Federated Learning for Medical Image Segmentation Code TMI2024
2023-10 Z. Wang and C. Ma Dual-Contrastive Dual-Consistency Dual-Transformer: A Semi-Supervised Approach to Medical Image Segmentation Code ICCV2023
2023-07 H. Wang and X. Li DHC: Dual-debiased Heterogeneous Co-training Framework for Class-imbalanced Semi-supervised Medical Image Segmentation Code MICCAI2023
2023-07 Q. Wei and Y. Zhou Consistency-guided Meta-Learning for Bootstrapping Semi-Supervised Medical Image Segmentation Code MICCAI2023
2023-07 H. Peiris and M. Harandi Uncertainty-guided dual-views for semi-supervised volumetric medical image segmentation Code Nature Machine Intelligence
2023-07 S. Gao and S. Zhang Correlation-Aware Mutual Learning for Semi-supervised Medical Image Segmentation Code MICCAI2023
2023-07 Z. Xu and R. Tong Ambiguity-selective consistency regularization for mean-teacher semi-supervised medical image segmentation Code MedIA2023
2023-06 P. Liu and G. Zheng C3PS: Context-aware Conditional Cross Pseudo Supervision for Semi-supervised Medical Image Segmentation None Arxiv
2023-05 Z. Zhang and Z. Jiao Cross-supervised Dual Classifiers for Semi-supervised Medical Image Segmentation None Arxiv
2023-05 Z. Zhang and Z. Jiao Self-aware and Cross-sample Prototypical Learning for Semi-supervised Medical Image Segmentation None MICCAI2023
2023-05 H. Cai and Y. Gao Orthogonal Annotation Benefits Barely-supervised Medical Image Segmentation Code CVPR2023
2023-05 H. Basak and Z. yin Pseudo-Label Guided Contrastive Learning for Semi-Supervised Medical Image Segmentation Code CVPR2023
2023-05 Y. Wang and X. Gao MCF: Mutual Correction Framework for Semi-Supervised Medical Image Segmentation Code CVPR2023
2023-05

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PublishedAug 1, 2026
UpdatedSep 17, 2026
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